The left ventricular is known to be influenced by both hemodynamic and non-hemodynamic factors. Body size and gender are the most representative non-hemodynamic factors. This study was performed to establish the influences of these variables including ambulatory BP on the variation of the left ventricular mass in healthy Korean adults.Design and method:
627 subjects (male = 270, female = 357), with a normal body mass index and blood pressure, were included in the analysis form database of the Yangpyung Epidemiologic cohort. The left ventricular mass was calculated using the equation: [1.04 × (IVSd + LVDd + PWTd)3-(LDVs3)] × 0.8 + 0.6. The stroke volume was calculated (mL/beat) using Teichholz's formula. The stroke work (SW in gram-meters/beat [g-m/beat]) was computed as ambulatory systolic BP × stroke volume × 0.0144.Results:
The stroke work (SW) was the most important factor associated with the LV mass (adjusted R2 = 0.422, p < 0.001), and body weight, age and gender were independent factors (adjusted R2 = 0.524). In a regression model, including stroke work, gender and height2.7, the LV mass was predicted by the equation: 79.4 + 6.35 × height (m2.7) + 0.45 × SW (g-m/beat)-15.6 × gender (male = 1, female = 2)(constant = 79.3 ± 14.7 g, adjusted R2 = 0.517, p = 0.001).Conclusions:
In this study using ambulatory BP, as with the previous studies, the stroke work, gender and height2.7 were important determinants of the left ventricular mass in Korean adults with a normal weight and normal blood pressure.