[PP.16.27] ECHOCARDIOGRAPHIC DIAGNOSIS OF HYPERTENSIVE HEART DISEASE: RELATION TO CARDIOVASCULAR RISK MARKERS?

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Abstract

Objective:

Echocardiography is fundamental in the analysis of hypertensive patients. The presence of criteria for the diagnosis of hypertensive heart disease (HD) is critical and constitutes a negative sign for the evolution of hypertension. We sought to study the relationship between the presence of HD and clinical and laboratory markers of cardiovascular risk.

Design and method:

We studied a population of 161 hospital outpatients followed for hypertensive syndrome.

Design and method:

All patients had an echocardiography, were we valued the presence of concentric parietal hypertrophy and diastolic dysfunction by Doppler study.

Design and method:

Prospectively, we registered the serum values for ultrasensitive C-reactive (CRP; mg/dl); total cholesterol (TC; mg/dL); LDL cholesterol (LDL, mg/dl); HDL cholesterol (HDL; mg/dL); Lipoprotein (a) (Lp (a), mg/dL) and uric acid (UricAc; mg/dl). We also valued age, sex, the presence of diagnosed peripheral arterial disease and the presence of uncontrolled blood pressure in 24 h blood pressure monitoring (UCBP). All patients with known active infectious disease, or inflammatory condition were excluded. The SPSS statistical package was used for analysis.

Results:

A population of 161 patients was selected. The chi-square test was used to compare proportions and MW test to compare continuous variables (expressed in median / interquartile deviation) between the groups with and without HD: respectively 1 and 0. See table below.

Results:

The correlations (Pearson) found between CRP vs CT, vs LDL, vs HDL, vs Lp (a) and vs UricAc, for the whole population are respectively: R2 = 0.006; R2 = 0.019; R2 = 0.001; R2 = 0.005 and R2 = 0.017. Just for group 1 the same correlations were respectively: R2 = 0.019, R2 = 0.057, R2 = 0.003, R2 = 0.013 and R2 = 0.003. See chart - correlation CRP vs LDL in Group 1.

Conclusions:

The presence of HD is linked to age. No significant differences were found for clinical and laboratory risk markers. However, the best correlation between the (recent) atherosclerotic risk marker CRP and the classic risk markers was found for LDL cholesterol.

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