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Hypertension (HTN) is a chronic medical condition. The prevalence of this vascular disease is rising all over the world. Hypertension can effect on the mental state and especially may decline cognitive function. The aim of this study is to evaluate the association between blood pressure components and cognitive functions and cognitive reserve.

Design and method:

In this cross sectional study, 500 subjects from general population of east Azerbaijan were randomly selected. Subjects underwent the neuropsychological tests and blood pressure measurement and were considered for the analysis of data.

Design and method:

Cognitive assessment was performed by means of mini-mental state examination (MMSE) and a comprehensive neuropsychological battery of validated tests “paper and pencil” relevant for exploring the areas of cognitive functions putatively related to cognitive decline.


The hypertensives (HT) were less efficient than the normotensives (NT) in the test of memory with interference at 10 sec (MI-10) (32%, P = 0.043), clock drawing test (CLOX) (26%, P < 0.001), and mini-mental state examination (MMSE) (7.4%, P = 0.02). Lower MMSE, MI-10, and CLOX were predicted by higher systolic (OR, 0.94, P = 0.032; OR 0.96, P < 0.001; OR 0.94, P < 0.001) and higher pulse blood pressure (PP) (OR 0.95, P = 0.04; OR 0.97, P < 0.001; and 0.92, P < 0.001).


This study contributes to the belief that a link exists between BP and cognition, higher values of systolic BP being associated to impaired cognitive function.

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