[PP.17.21] AN ASSESSMENT OF NEUROTROPHIC THERAPY EFFECT ON NERVE GROWTH FACTOR LEVEL IN PATIENTS WITH POST STROKE APHASIA AND DIABETES MELLITUS

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Abstract

Objective:

An important role in the maintenance and regulation of the functional integrity of the nervous system playing neurotrophic factors? including nerve growth factor, NGF. It is found that the mechanism of neuronal cell death largely depends of deficiency of neurotrophic effects. This is particularly important in patients with diabetes mellitus. Cerebrolysin is a compound with neurotrophic and neuroprotective activity. We carried out an open randomized controlled study to explore the changes in the rate of speech recovery and NGF concentrations in patients with left-hemisphere stroke and diabetes mellitus type 2 who received cerebrolysin

Design and method:

A study included 60 inpatients of the Center of Speech Pathology and Neurorehabilitation. Neuropsychological examination was performed at baseline and after the treatment was completed. We determined aphasia type and quantitatively assessed speech in scores which reflected the severity of speech impairment. NGF serum concentrations were measured.

Results:

Clinical efficacy of cerebrolysin (intravenously in dose 20 ml in 100 ml of physiological solution, 5 days a week, during 4 weeks) used in addition to standard neurorehabilitation measures in patients with post stroke aphasia of different severity was demonstrated. This treatment was most effective in patients with very marked and marked speech impairment that was confirmed by the maximal possible improvement of speech during the first course of neurorehabilitation measures. A significant increase in NGF concentrations was an additional evidence of this improvement.

Conclusions:

The use of cerebrolysin in the complex treatment of patients with post stroke aphasia of different severity improves the prognosis of their rehabilitation.

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