[PP.18.07] VASCULAR AND METABOLIC PROFILE IN PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

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Abstract

Objective:

Assessment of vascular and metabolic profile in patients with and without coronary artery disease (CAD). CAD was diagnosed with at least one coronary artery stenosis > = 50%.

Design and method:

We divided 100 patients in two groups: CAD+ patients with coronary artery disease and CAD- patients without coronary artery disease. All patients underwent coronary angiography because of angina.

Design and method:

The average age of them [yrs]: 60 and 53 (*p < 0,05).

Design and method:

Ankle-brachial index (ABI), carotid intima-media thickness (IMT) and pulse wave velocity (PWV) were evaluated. Following measurements were taken: BMI, total cholesterol (Tchol), HDL, LDL, TG, fasting plasma glucose, HA1C and uric acid.

Design and method:

Statistical calculations were performed in the StatSoft Statistica 10. For comparison of variables with a normal distribution and equal variances we used the t-test for unrelated samples.

Results:

We revealed following results in both groups: CAD+ and CAD- respectively [*for p < = 0,05; **for p < 0,001; NS- negligible statistically].

Results:

In CAD group patients were characterized by lower: ABI, Tchol, HDL, LDL cholesterol level and higher: IMT, glucose, HA1C and uric acid level than patients without CAD.

Conclusions:

1. Patients without coronary artery disease were characterized by minor vascular damages assessed by ABI and IMT than patients with coronary artery disease.

Conclusions:

2. Patients with coronary artery stenosis were characterised by worse metabolic profile of glucose, HA1C and uric acid than patients without CAD.

Conclusions:

3. Lower levels of total and LDL cholesterol in coronary artery disease group were caused by advanced pharmacological and non-pharmacological therapy of the primary disease.

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