[PP.21.04] INTERLEUKIN-17 RELATED TO RISK FACTORS IN HYPERTENSIVE PATIENTS

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Abstract

Objective:

Recently Interleukin 17 (IL-17) had been shown implicated in the pathogenesis of numerous autoimmune diseases, obesity, and cardiovascular diseases. The purpose of the study was to investigate the serum concentration of IL-17 and its association with cardiovascular risk factors in hypertensive patients.

Design and method:

Ninety hypertensive patients (47 men, 43 women) aged 56 ± 4.1 years were prospectively enrolled for this study. Serum IL-17 had been measured by ELISA method in all participants after wash-out period. All patients were evaluated for anthropometry, cardiovascular risk factors and 24-hour blood pressure monitoring. The results were analysed using two-sided Fisher's exact test and the respective odds ratio (OR) was calculated.

Results:

Mean serum level of IL-17 was significantly higher (6.7 pg/ml) in high-risk hypertensive patients compared with moderate (on 33%, p = 0,03) and low-risk (on 46%, p = 0,01) patients. In high-risk hypertensive patients increased serum IL-17 above 5.5 pg/ml had been significantly associated with history of previous stroke (OR = 2.43; 95% confidence interval [CI], 1.15 to 3.84), high night-time systolic blood pressure level (OR = 1.87; 95% CI, 1.18 to 2.78) and c-reactive protein (OR = 3.42; 95% CI, 1.65 to 5.62). No relationship between IL-17 and body mass index as well as patient's age had been revealed.

Conclusions:

High-risk hypertensive patients had elevated level of interleukin-17, which is related to cerebrovascular lesion, high night-time systolic blood pressure level and marker of inflammation. These associations could indicate on potential role of autoimmune cytokines in hypertension progression.

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