The association between essential hypertension (EH) and low scores of health-related quality of life (H-rQoL) is well established, while inflammation is emerging as a precursor and predictor of cardiovascular disease. We assessed the hypothesis that there might be a possible association between high sensitivity C-reactive protein (hs-CRP), a time-honored marker of inflammation and H-rQoL, in the setting of EH.Design and method:
We studied 154 consecutive subjects (aged= 58 ± 17 years, male=78), with stage I-II untreated uncomplicated EH (office blood pressure=150/98 mm hg). In all participants venous blood samples were drawn for evaluation of hs- CRP levels. To assess the H-rQoL, the widely validated Short Form 36 (SF-36) General Health Survey questionnaire was administered. The SF-36 is a generic H-rQoL instrument that includes eight subscales. These subscales were further grouped into two summary scales: the physical component summary (PCS) and the mental component summary (MCS).Results:
There was a significant negative correlation between hs-CRP levels and scores in six dimensions of SF-36, thus with the total score. (Table)Conclusions:
In conclusion,there is an intriguing link between inflammation and low scores of health-related quality of life in the setting of essential hypertension. The pathophysiological substrate of these interrelationships needs further investigation through large scale prospective studies.