[PP.23.05] CENTRAL BLOOD PRESSURE AND ARTERIAL WAVE REFLECTION IN RESISTANT HYPERTENSION

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Abstract

Objective:

The aim of this study was to estimate central blood pressure (BP) with indexes of augmentation, pulse wave velocity and variability of BP in ambulatory blood pressure monitoring (ABPM) among patients with resistant hypertension (RHT).

Design and method:

We examined 41 subjects with newly diagnosed HT without any treatment, 31 with well controlled HT and 31 with RHT. We performed ABPM using SpaceLabs; carotid-femoral pulse wave velocity (PWV) and measurements of central BP as well as indices of arterial wave reflection using SphygmoCor.

Design and method:

One-way ANOVA and post-hoc Tukey test were used to compare differences between the groups.

Results:

The characteristics of three groups was summarized in table 1:

Results:

Data in Table are presented as mean ± standard deviation (SD) or mediana[interquartile range]

Results:

Statistically significant differences between groups are denoted: a–group 1 vs 2; b–group 1 vs 3; c–group 2 vs 3

Results:

SBP–systolic blood pressure, DBP–diastolic blood pressure, SBPC-central systolic blood pressure, DBPC-central diastolic blood pressure, BMI-body mass index, AG-augmentation, Alx1-augumentation index 1, Alx2-augumentation index 2,PWV-pulse wave velocity

Conclusions:

Patients with RHT, in comparison to group with well controlled HT, have increased central BP and variability of BP in ABPM. Furthermore, RHT group was characterized by greater PWV and indices of arterial wave reflection (AG, Alx1, Alx2) when this group was compared with newly diagnosed HT group. However, there were no such differences when compare with controlled HT with exception of AG and these differences disappeared after adjustment for age. Our results suggest that age exerts stronger influence on PWV and wave reflection then BP.

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