[PP.23.19] METABOLIC INDICATORS OF CARDIOVASCULAR DISEASES IN RESISTANT HYPERTENSION

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Abstract

Objective:

The aim of this study was to evaluate metabolic profile among patients with resistant hypertension (RHT) as well as to assess differences between subjects with newly diagnosed, well controlled and resistant hypertension (HT).

Design and method:

We examined 41 subjects with newly diagnosed HT without any treatment, 31 with controlled HT and 31 with RHT. We performed ABPM using SpaceLabs 90207, 90217. Traditional metabolic risk factors of cardiovascular diseases (CVD) such a: age, sex, body mass index (BMI), waist-hip ratio (WHR) were assessed as well as plasma glucose level, total cholesterol, LDL, HDL, TAG, insulin, cortisol, high-sensitivity CRP (hsCRP) and glycated haemoglobin (HbA1c).

Design and method:

One-way ANOVA and post-hoc Tukey tests were used to compare differences between the groups.

Results:

The characteristics of three groups are summarized in table 1:

Results:

Data in Table are presented as mean ± standard deviation(SD) or mediana[interquartile range]

Results:

Statistically significant differences between groups are denoted: a–group 1 vs 2; b–group 1 vs3; c–group 2 vs 3

Results:

SBP–mean systolic blood pressure from 24 hours monitoring, DBP–mean diastolic blood pressure from 24 hours monitoring,

Conclusions:

Subjects with RHT were characterized by higher level of fasting glucose and HbA1c in spite of lack differences in BMI or WHR. Of note, no differences in lipid profile or inflammation were observed between subjects with newly diagnosed hypertension, those with controlled HT or resistant hypertension.

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