[PP.23.22] CORRELATION CENTRAL BLOOD PRESSURE RESPONSE WITH CREATININ, EGFR AND HEART RATE AFTER RENAL DENERVATION IN PATIENTS WITH RESISTANT HYPERTENSION IN UKRAINE

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Abstract

Objective:

The purpose of this analysis was to determine which correlations relationships were associated with renal denervation efficacy in a cohort of 8 patients.

Design and method:

We screened 436 subjects selected 8 patients (1,8%) (5 male, 3 female) with true resistant hypertension for renal denervation (RDN) by Simplicity catheter (Medtronic). Mean age 52,1 ± 3,8 years. At baseline office blood pressure (BP) was 156,9/95,0 ± 2,9/2,1 mmHg. Patient took in average 5 drugs. Mean baseline 24ABPM was 151,4 ± 4,8/82,6 ± 4,8 mmHg, 24HR was 65,3 ± 2,7 b.p.m.

Results:

Mean follow-up was 2,3 ± 0,3 years. 1 month after RDN office SBP decreased by 8,0 ± 4,3 mmHg, cBP −21,1 ± 6,4 mmHg and 24SBP decreased by 7,7 ± 4,7 mmHg. 2 years after RDN office SBP decreased by 29,1 ± 6,8 mmHg, cSBP decreased by 7,6 ± 5,6 mmHg and 24SBP decreased by 13,3 ± 4,6 mmHg. cBP after 1 month correlated with decreased delta office HR 1 month (R = −0,768; P = 0,001), cBP after 6 month correlated with delta office HR 1 month, (R = −0,700; P = 0,024); delta office HR 6 month (R = −0,989; P = 0,001) delta office HR 2 years (R = −0,800; P = 0,005). Decreased cBP after 2 years was associated with less decreased HR24 (ABMP) after 1 month (R = −0,975; P = 0,001) and with less decreased HR24 (ABMP) after 2 years (R = -0,800; P = 0,017). eGFR after 1 month RDN direct correlated with delta office HR 7 days (R = 0,800; P = 0,017); with delta office HR 6 month (R = 0,998; P = 0,001); with delta office HR 2 years (R = 0,800; P = 0,017). Creatinin after 6 month correlated with delta office HR 7 days (R = −0,866; P = 0,026). Creating after 2 years correlated with delta office HR 1 month (R = −0,800; P = 0,017). If office HR was not decreased after 7 days, 1 month, it was associated with higher creating 6 month and 2 years after RDN.

Conclusions:

Poor decreased office HR after RDN 7 days, 1 month, 6 month or 2 years it was associated with less decreased central BP after 1, 6 month, increased creatinin after 6 month and 2 years; and associated with decreased eGFR 7 days and 1 month after RDN. Less decreased central BP after 2 years was associated with less decreased HR (ABMP) after 1 month, 2 years RDN.

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