to assess serum cytokines levels in patients with idiopathic pulmonary arterial hypertension (IPAH) depending on the result of acute vasoreactivity test (AVT).Design and method:
In the study we included 61 IPAH patients (mean age 32,4 ± 3,2 years).Design and method:
Patients were divided into two groups depending on pulmonary artery vasodilator reactivity. In all patients were investigated by serum cytokines levels. Results were compared with control group, 10 healthy volunteers served of control group.Results:
In all IPAH patients the levels of IL–1β were not different and were within normal range (p > 0,05) (Table 1). But at one-third of patients the levels of IL–1β were higher than in the control group. In both groups the level of IL-6 TNFα, MIP1α, sVCAM was significantly higher as compared to control levels.Results:
A high level of IL-6 evidence about the formation of an noadequate response organism on injury or inflammation. Intensity of inflammation and endothelial dysfunction and their interaction, noting the existence of a significant positive correlation between IL-6 and ET-1 (r = 0,421; p < 0,05). High levels of IL-6 TNFα and MIP1α indicate the presence of inflammation at all stages of development IPAH. IL-8 levels was significantly higher in nonresponder group and pointed to a more pronounced inflammatory reactions sharpness.Results:
The differences between the groups of responders and nonresponders confirms a significant correlation between IL-8 and NT-proANP (r = 0,342; p < 0,05), NT-proBNP (r = 0,428; p < 0,05), and NA (r = 0,468; p < 0,05). In all IPAH patients the level of IL-10 was higher than control values. Only in nonresponder group the level of INFγ was lower than in the control group. The marker of vascular injury s ICAM was significantly higher than in the control group and the maximum concentration observed in patients without reserve vasoreactivity.Conclusions:
The levels of inflammatory cytokines were significantly increased in the nonresponder group in compare with responder group. The most elevated levels of inflammatory mediator were IL-8 and s ICAM.