[PP.27.24] EFFECTS OF ASTHMA SEVERITY ON LEFT VENTRICLE OF CARDIAC REMODELING IN PATIENTS WITH ARTERIAL HYPERTENSION

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Abstract

Objective:

To reveal the characteristics of left ventricle of cardiac remodeling at different severity degrees of bronchial asthma (BA) on the background of hypertension.

Design and method:

91 patients were involved with varying BA severity in the step of controllability associated with arterial hypertension (AH) 1, 2 severity. Of these, 26 patients (29%) with mild BA, 34 (37%) with an average severity of BA, 31 (34%) - severity of severe BA. A group of 30 patients with AH 1,2 degrees and a group of 32 people with BA were taken for a comparative analysis. All examined patients were outpatients and were taken adequately matched basic therapy on BA with inhaled corticosteroids (ICS). The patients used a beta2-agonists short action on demand. Group of patients with AH 1,2 degrees, n = 30, and a group with different degrees of BA in the stage of control n = 32, were taken for comparative analysis. The diagnosis of AH and extent of increase the blood pressure (BP) - on the basis of criteria of WHO 2013. In groups of comparison there were no statistically significant distinctions of an average the BP, groups were comparable on age, sex and an experience of AH (p > 0,05). All patients were performed the echocardioscopy on Acuson 128XP /10c (USA).

Results:

The Index of weight of myocardium of left ventricle (IWMLV) and the thickness of a back wall of the LV (TBWLV) were more in groups with AH. IWMLV in group BA-87,55 ± 2,65 g/m2, AH-112,1 ± 1,97 g/m2, BAMAH-109,18 ± 1,16 g/m2, p = 0,004, BAAAH-123,1 ± 1,42 g/m2, p = 0,001, p = 0,0015, BASAH-128,45 ± 1,91 g/m2, p = 0,001, p = 0,0001. TBWLV in BA group-0,93 ± 0,02 cm, AH-1,08 ± 0,03 cm, BAMAH-0,98 ± 0,01 cm, BAAAH-1,13 ± 0,03 cm, p = 0,004, p = 0,001, BASAH-1,27 ± 0,03 cm, p = 0,001, p = 0,0001. Results the following are received during studying of the final diastolic size (FDS): BA-4,90 ± 0,06 cm, AH-5,01 ± 0,06 cm, BAMAH-5,01 ± 0,06 cm, BAAAH-5,19 ± 0,06 cm, BASAH-5,65 ± 0,06 cm.

Conclusions:

Patients with the combined pathology had IWMLV and TBWLV more, since BAAAH group, than similar indicators of groups with the isolated BA and AH. FDS didn’t differ at investigated with the combined pathology from a similar indicator at groups of BA and AH, then is higher the severity of bronchial obstruction, we see a tendency to its increase.

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