[PP.29.06] WHICH TARGET ORGAN IS MORE VULNERABLE FOR METABOLIC SYNDROME?

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Abstract

Objective:

Different components of metabolic syndrome (MS) and risk factors can play important role in the development of cardiovascular changes. The aim of the study was to assess association of MS and its components with target organ damage (TOD) in a cross-sectional study of relatively healthy bank employers.

Design and method:

Out of 1,600 random sample of office workers, a group of 383 participants with at least one component of MS and without cardiovascular complications was selected (mean age 46.6 ± 9.0 years, 214 females (64.6%)). TOD was assessed by echocardiography (left ventricular hypertrophy (LVH)), carotid ultrasound, applanational tonometry (pulse wave velocity (PWV)), ankle-brachial index (ABI) by linear Doppler, and urine albumin excretion (UAE) measurements. Anthropometry, vital sign assessment, and biochemistry were performed according to standard protocols.

Results:

Prevalence of TOD according to number of MS components is presented in Table.

Results:

Patients with the 3 and more MS components are at risk of TOD, but significant association was documented only for atherosclerotic plaques. Multiple linear regression revealed association of age with all subclinical markers of TOD.

Conclusions:

MS components number accumulation is associated with acceleration of TOD signs. Carotid atherosclerosis is the most vulnerable marker associated with MS components.

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