To identify predictors of biochemical showing increasing vascular wall stiffness in patients with hypertensionDesign and method:
The study involved 130 patients with mild-to moderate hypertension, hyperlipidemia, and mild abdominal obesity. Group 1 included 53 patients with hypertension, the second group - 77 patients with arterial hypertension and abdominal obesity. Both groups were comparable in age, duration of hypertension, office blood pressure. The study of elastic properties of the vascular wall was performed by sphygmography on the unit Vasera VS- 1000 Series (Japan), with a performance rating: PWV-R, PWV-L - pulse wave velocity by elastic arteries. Biochemical lipid parameters were assessed - TC, LDL-C, HDLC, TG; inflammatory and endothelial markers – hs CRP, homocysteine, tumor necrosis factor, nitrites, endothelin 1.Results:
Binary regression method identified biochemical predictors: from lipid profile-patients 1 and 2 groups in terms of increased levels of TC > 5.0 mmol / l at its further increase of 1 mmol / l increase the likelihood of PWV -L increases to 14.7 times (p = 0.05) in group 1 and 2 groups in terms of reduced HDL values < 1.2 mmol / l at its further decline of 1 mmol / l increase the likelihood of PWV-L increases by 72% (p = 0.026). Parameters of endothelial dysfunction - the 2 groups of patients with a decrease in the initial level of nitrite to 1 nmol / ml increase the likelihood of PWV-L increases by 46% (p = 0.035). Method of artificial neural networks used to confirm that the vascular wall stiffness is directly related to biochemical markers such as the level of TC, HDL, hs-CRP, homocystein and endothelin-1.Conclusions:
Predictors of biochemical control, in particular, total cholesterol, HDL cholesterol, hs CRP, homocysteine and endothelin -1 affects the rigidity of the vascular wall of hypertensive patients with abdominal obesity.