[PP.30.18] EFFECTS OF A COMBINED BLOOD PRESSURE AND LIPID-LOWERING NUTRACEUTICAL ON MILDLY HYPERTENSIVE HYPERCHOLESTEROLEMIC SUBJECTS: A PILOT, DOUBLE-BLIND, PLACEBO-CONTROLLED, RCT

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Abstract

Objective:

A number of nutraceuticals have demonstrated to significantly lower blood pressure or lipid levels in humans. Our aim was to evaluate the effect of a combination of both blood pressure and lipid lowering nutraceuticals in mildly hypertensive hypercholesterolemic subjects.

Design and method:

This is a pilot, double-blind, randomized, placebo-controlled, clinical trial carried out on 30 mildly hypertensive hypercholesterolemic subjects in primary prevention for cardiovascular disease, randomized to active treatment or placebo for 2 months. Active treatment contained red yeast rice extract (with 10 mg monacolin per dose), an NO-donor, magnesium, and vitamins.

Results:

The tested product was well-tolerated by all patients. Subjects in active treatment experienced a significant improvement in morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo (see table).

Conclusions Conclusion:

A combined blood pressure and lipid lowering nutraceutical improved morning SBP, DBP, MAP, evening SBP, LDL-C and estimated CV risk vs. placebo in mildly hypertensive hypercholesterolemic subjects.

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