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Essential hypertension (EH) has a negative impact on health-related quality of life (H-rQoL) while dyslipidemia very often accompanies the hypertensive sequelae. We assesed the hypothesis that the combination of EH and dyslipidemia may have an additive effect on H-rQoL.We studied 145 subjects with newly diagnosed stage I-II untreated EH (aged 56 ± 7 years, 47 = dyslipidemic, office blood pressure = 156/92 mmHg). Venous sampling was performed for estimation of lipidemic profile. The validated Greek version of Short Form 36 (SF-36) General Health Survey questionnaire was administered. The 8 subscales of SF-36 were further grouped into two summary scales: the physical component summary scale (PCS) and the mental component summary scale (MCS). Non-parametric Mann-Whitney and Spearmann rho tests were performed.Dyslipidemic hypertensives demonstrated significantly lower scores in all SF-36 dimensions compared to non dyslipidemic (Table). There was a negative correlation between scores in general health and the total SF-36 score with serum triglycerides level (r = -0.284 p = 0.009, r = -0.287 p = 0.014, respectively).Dyslipidemia exerts an additive detrimental effect on quality of life in the setting of essential hypertension. Whether the above mentioned association contributes to the high cardiovascular risk observed in those patients remains to be determined in future studies.