[PP.32.16] RELATIONSHIP BETWEEN SUBCLINICAL ORGAN DAMAGE, CIGARETTE SMOKING AND CARDIOVASCULAR RISK IN BOTH GENDERS OF HYPERTENSIVE PATIENTS

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Abstract

Objective:

Assessment of correlation between subclinical organ damage, cigarette smoking and cardiovascular risk in both genders of hypertensive patients.

Design and method:

We divided 50 patients who smoked cigarettes in the past with arterial hypertension in two groups: A: 25 women; B: 25 men. The average age of them [yrs]: A: 55 and B: 57. Ankle-brachial index (ABI), pulse wave velocity (PWV), carotid intima-media thickness (IMT) and cardiovascular risk according to SCORE scale were evaluated. We noted the number of pack-years in all patients.

Design and method:

Statistical calculations were performed in the StatSoft Statistica 10. The t-student test was used for the statistical analysis, ρ Spearmann was taken to analyze the correlation of statistically significant values.

Results:

We revealed following results in both groups: comparison A vs B respectively (SD) [*for p < = 0,05; **for p < 0,001; NS- negligible statistically]: ABI: 0,94(0,16) and 1,01(0,14) NS; PWV [m/s]: 10,68 (2,29) and 12,54 (3,01) **; IMT [mm]: 0,73(0,15) and 0,81(0,17) *; number of pack-years: 9,64(11,23) and 15,22(20,47) *; SCORE: 3,16 (2,49) and 7,00 (5,10) **. Women were characterized by a lower IMT, PWV and number of pack-years than men. In this group the above-mentioned parameters were correlated together.

Results:

In women group there were significant negative correlation between ABI and SCORE scale and positive correlation between IMT and SCORE scale. In men group there was positive correlation between number of pack-years and SCORE scale.

Conclusions:

1. Women with hypertension were characterized by minor vascular damages assessed by PWV and IMT than men. This is probably due to lower number of pack-years in this group.

Conclusions:

2. ABI and IMT in hypertensive women were proportional to the cardiovascular risk.

Conclusions:

3. The number of pack-years in hypertensive men were proportional to the cardiovascular risk.

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