[PP.33.13] LEFT VENTRICLE DIASTOLIC FUNCTION IN A COHORT OF TREATED HYPERTENSIVE PATIENTS

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Abstract

Objective:

Diastolic dysfunction (DD) is highly prevalent consequence of hypertension, and its occurrence, among others, relies on both the duration, as well as the control of blood pressure. Although the presence of clinically silent DD confer the cardiovascular risk, current ESH guidelines do not include the presence of DD in the list of subclinical organ damage which delineates patients’ risk profile.

Objective:

Based on the current echocardiographic recommendations we aimed to assess both the occurrence and the severity of diastolic dysfunction DD in a cohort of 853 treated hypertensives.

Design and method:

We enrolled consecutive 853 hypertensive subjects (45.8% females). Routine echocardiography was performed (Vivid 7 Pro). Diastolic function was assessed and graded according to the recommendations of the European Association of Echocardiography. Additionally, clinical history, laboratory tests and ABPM were recorded. Patients with overt heart and cerebrovascular diseases were excluded from the analyses.

Results:

Patients were characterized as follows: age = 54.5 ± 13.5 y.o.; BMI = 30.0 ± 5 kg/m2; hypertension duration = 15 ± 10 years; blood-lowering treatment duration = 13 ± 9 years. 23% of participants had established type 2 diabetes mellitus, 76.5% dyslipidaemia, 7.9% chronic kidney disease. 648 (76%) patients were eligible for echocardiographic analyses. The distribution of diastolic function characteristics was as follows: normal = 26% (18% vs. 33% for females and males, respectively); grade 1 DD = 45% (45% vs. 45% for F vs. M); grade 2 DD = 29% (37% vs. 22%). None of the patients were diagnosed with grade 3 DD. Patients required 2.9 ± 1.5 blood-lowering drugs, and the hypertension control over 24 h ABPM was as follows: SBP = 129.2 ± 9.1 mmHg; DBP = 77.0 ± 9.2 mmHg; 24 h HR = 71.5 ± 9.1 bpm.

Conclusions:

Mild-to-moderate diastolic dysfunction is highly prevalent in satisfactory controlled, long-lasting hypertensives.

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