[PP.34.07] DIETARY NITRATE DECREASED BLOOD PRESSURE PROFILES IN CPAP NAÏVE OBSTRUCTIVE SLEEP APNOEA SYNDROME: A 2 WEEK, DOUBLE-BLIND RANDOMIZED, PLACEBO-CONTROLLED CROSSOVER TRIAL

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

To assess the effect of 14d daily nocturnal nitrate (NO3) supplementation compared to matching placebo (PL) among a group of well-characterized, untreated subjects with severe obstructive sleep apnoea syndrome (OSAS) on ambulatory BP, plasma nitrite, exhaled nitric oxide (eNO) and nocturnal pulse oximetry.

Design and method:

We recruited 12 with severe OSAS (mean AHI = 74, mean age = 52y, mean BMI = 31 kg/m2) to this 14d, double-blind, randomized, placebo-controlled, crossover trial. Subjects were tested on three occasions, baseline (day 1), midpoint, (day 15) and endpoint (day 29) – before and after each intervention period.

Conclusions:

Daily dietary nitrate for 14d was well-tolerated, safe and led to increases in plasma nitrite and eNO as ell as decreases in BP profiles, particularly nocturnally.

Related Topics

    loading  Loading Related Articles