[PP.34.08] PECULIARITIES OF INFLAMMATORY MARKERS IN MIDDLE-AGED MALE PATIENTS WITH ARTERIAL HYPERTENSION, OBESITY AND OBSTRUCTIVE SLEEP APNEA SYNDROME

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Abstract

Objective:

Obesity and obstructive sleep apnea syndrome (OSAS) are the conditions associated with inflammation. The aim of this study was to explore peculiarities in serum levels of inflammation markers in patients with arterial hypertension (AH) with or without obesity and OSAS.

Design and method:

In the study we included 10 healthy volunteers (group 1) and 52 middle-aged male patients with AH. According to BMI and AHI (apnea/hypopnea index) patients were divided into 3 groups: group 2 patients solely with AH (n = 17), group 3 (n = 15) patients with AH and obesity, without OSAS and group 4 (n = 20) patients with AH, obesity and severe OSAS. Patients were healthy in terms of chronic heart disease, diabetes mellitus, chronic kidney disease, manifested autoimmune or inflammatory disease. All blood samples were obtained after initial diagnostics, in the morning, in fasting condition; initially patients were not on any medication.

Results:

Patients were examined for levels of fibrinogen, CRP, hsCRP, IL 6, sCD40L, IL 1b, IL 2R α, IL 6, TNF α, ICAM and VCAM.

Results:

Levels of fibrinogen were higher in group 2 and group 4 vs control group 1.

Results:

The highest levels of CRP and hsCRP were detected in group 4: CRP 0,55 (0,26–0,83), hsCRP 4,52 (2,47–6,56), but statistically significant difference was obtained between group 1 and group 2 vs group 4.

Results:

IL 2R α was the highest in group 3 with high diversity in levels, and statistically higher in comparison with group 2.

Conclusions:

Obese patients with AH and severe OSAS have elevated levels of CRP and hsCRP compared to age and BP matched patients with solely AH, but not with patients with concomitant obesity, suggesting a confounding role of OSAS together with obesity in promoting inflammation.

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