[PP.34.09] MRI MEASUREMENT OF AIRWAY SOFT TISSUES PARAMETERS IN PATIENTS WITH OBSTRUCTIVE SLEEP APNOEA

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Abstract

Objective:

To compare the size of airway soft tissues parameters measured by MRI in obese patients with and without obstructive sleep apnea (OSA).

Design and method:

We included 74 obese males (mean age 31 to 66 years). All patients were divided into 3 groups. Group 1 - included 42 patients with obesity (body-mass index (BMI) of 35,1 [31,8; 37,6] kg/m2) and severe OSA (apnea-hypopnea index (AHI) - 48,5[40; 60]). Group 2 - included 30 patients with obesity (BMI of 33,6[32,05; 34,6]) with mild OSAS (AHI of 8[5;12]). And group 3 (normal group) - 20 healthy volunteers without obesity (BMI - 24[22,8;24,85]) and without OSAS (AHI - 1[0;3]). All patients underwent MRI using 3T scanner with measurements of the soft palate volume (VSP), tongue volume (VT), fat volume in the tongue, volume of the lateral walls (VLW) of the RP (retropalatal) and RG (retroglossal) regions, the area of maximum airway constriction (SmaxCA) at the level of RP and RG regions.

Design and method:

The pharynx was divided into the following segments: from the hard palate to the lower edge of the soft palate (level RP - region retropalatal) and from the lower edge of the soft palate to the bottom of the epiglottis (level RG - region retroglossal).

Results:

Patients with OSAS showed higher values of VT, sm3 - (77,4 [70,9;93,4] vs. 54,8[48,3;66,2] vs. 44,9[33,9;49,4]), the volume of fat in the tongue, sm3- (32,8[29,6;36,5] vs. 22,8[20,2;24,5] vs. 13,5[12,2;15,7]),VSP, sm3 - (8,4[7,4;9,8] vs. 6,4[5,5;7,4] vs. 3,3[2,9;4,1]), VLW RP, sm3 (12,7[10,7;14,8] vs. 8,3[6,4;10,5] vs. 3,1[2,8;3,7]), VLW RG, sm3 (11,5[9,3;13,7] vs. 7,5[5,8;91] vs. 2,9[2,4;3,8]), and lower values of SmaxCA at the level of both RP, sm2 (4,6[3,2;6,5] vs. 8,5[6,4;11,4] vs. 12,9[10,4;17,3],) and RG, sm2 (16,9[12,4;2,1] vs. 21,5[16,9;25,2] vs. 27,3[24,7;30,4].) comparing with the control and normal groups, p < 0.05 for all comparisons.

Conclusions:

Patients with obesity and severe OSA have significantly higher volumes of soft tissues and lower area of maximum airway constriction in comparison with the patients with mild OSA and obesity. These values can be used for OSA detection.

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