[PP.36.14] COMPARATIVE CHARACTERISTICS OF LOCAL STIFFNESS PARAMETERS IN HEALTHY SUBJECTS AND PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREES

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Abstract

Objective:

To conduct a comparative analysis of the local stiffness parameters of the carotid arteries in healthy subjects and patients with arterial hypertension (AH) 1-2 degrees.

Design and method:

Study involved 56 subjects. Group 1 included 34 healthy normotensive subjects (mean age 47,1 ± 7,1 years; SBP 117,4 ± 6,9 mmHg, diastolic blood pressure 74 (67,5; 80,0) mmHg). Group 2 consisted of 22 patients with hypertension of 1-2 degrees (average age 47,5 ± 6,9 years, SBP 146,2 ± 7,1 mmHg, diastolic blood pressure 93,0 ± 6,7 mmHg). Local arterial stiffness were evaluated by the ultrasonic device My Lab 90 («Esaote», Italy) using the echotracking software on the following parameters: local systolic (Loc Psys) and diastolic pressure (Loc Pdia), the coefficient of transverse extensibility (DC), the coefficient of lateral compliance (CC), stiffness index β, local carotid pulse wave velocity (PWV).

Results:

According to echotracking the local pressure values - Loc Psys and Loc Pdia in group 1 were the following: 102,7 (96,7; 110,4), and 70 (70,0; 80,0) mmHg.; group 2 - 8,0 and 123,4 ± 90,0 (80,0; 95,0) mmHg (p < 0,05). DC indicator decreased with increasing pressure: in healthy normotensive individuals - 0,02 (0,02; 0,03) 1/kPa, in hypertensive patients - 0,01 (0,01; 0,02) 1/kPa (p < 0,05). Values of local compliance of the CC in group 1 were 0,81 (0,63; 1,17) mm2/kPa, group 2 - 0,55 (0,45; 0,73) mm2/kPa (p < 0,05). Stiffness index β prevailed in patients with hypertension (10,5 (8,1; 12,4)) compared with healthy individuals (7,5 ± 2,5) (p < 0,05). The subjects in the control group had lower values of PWV - 6,3 ± 1,0 m/s in individuals with hypertension were 8,8 (8,1; 9,5) m/s (p < 0,05).

Conclusions:

According to echotracking an impairment of most parameters of local rigidity has been revealed in patients with hypertension. Progressive remodeling in conditions of high blood pressure is accompanied by a decrease in the damping function of the vascular wall, as evidenced by an increase in pulse wave velocity, stiffness index, and reduced coefficients of compliance and distensibility of the carotid arteries.

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