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Vascular age is the apparent age of the arteries that can be affected by genetic predisposition and lifestyle risk factors. Subjects whose vascular age is younger than chronological age might have lower cardiovascular risk. The aim of our study was estimate protective factors, which can be associated with younger vascular age in Russian population according to VaSera examination results.1600 apparently healthy participants aged 25–65 years were randomly selected from Saint-Petersburg inhabitants (ESSE-RF study). Fasting lipids, glucose (Abbott Architect 8000 (USA)) and blood pressure (BP) measurement by Omron (Japan) were performed. Cardio-ankle vascular index (CAVI) was detected by VaSera VS-1500 (Fukuda, Japan). We presumed definition of younger vascular age - it the biological age exceeded vascular age calculated from pressure independent stiffness index (CAVI) >4 years. Hypertension was considered as BP> = 140/90 mmHg or antihypertensive treatment, diabetes type 2 was considered as fasting glucose> = 7.0 mmol/l or treatment. Multiple regression analysis was applied (SPSS Statistics 20).Data of 1361 subjects were suitable for analysis, 391 patients (28,7%) had vascular age younger than chronological (281 (71,8%) women and 110 (28,1%) men, Ð<0,001). These subjects were younger than other participants also according biological age (43,4±10,8 vs 45,8 ± 11,8 years, p < 0.05).Table 1. Determinants of younger vascular age in general population.Female gender was associated with higher probability to have a younger vascular age comparing to chronological age might be through higher HDL level despite the absence of direct associations. Dyslipidemia and hypertension decreased a probability to have younger vascular age.