[PP.38.10] BLOOD PRESSURE VARIABLES, BODY MASS INDEX AND ARM CIRCUMFERENCE PREDICT ARTERIAL STIFFNESS AND EARLY ARTERIAL AGING IN SEDENTARY AND PHYSICALLY ACTIVE SUBJECTS

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Abstract

Objective:

The present study aimed to compare the predictive value of blood pressure and anthropometric variables for arterial stiffness, endothelial dysfunction and early arterial aging (EAA) in sedentary and physically active subjects.

Design and method:

A total of 90 study participants underwent arteriography. Blood pressure variables, pulse wave velocity (PWV), brachial augmentation index (AixBrach) and arterial age (AA) were assessed. Considering physical activity level, the participants were divided in 2 groups, as follows: 61 were involved in leisure physical activity or physical work and 29 were sedentary. Overweight and obesity were detected in 11 patients of the first and 16 of the second group.

Results:

Systolic blood pressure, diastolic blood pressure, systolic blood pressure in the aorta, pulse pressure in the aorta (PPAo), AixBrach, PWV and AA were as follows: 121 ± 12 mmHg, 72 ± 9.92 mmHg, 111 ± 14 mmHg, 39 ± 2.27 mmHg, -45 ± 3.63%, 7.48 ± 1.39 m/s and 34.62 ± 3.15 years, respectively. Significant correlations were found between blood pressure, anthropometric and arteriographic variables. The best correlation was between AixBrach and PPAo (r = 0.59). Obese and overweight sedentary participants were most likely to have endothelial dysfunction (OR = 2.31), high normal blood pressure and hypertension (OR = 1.64), and increased pulse wave velocity (OR = 2.61). The risk decreases in obese physically active participants (OR = 1.99, 0.29 and 2.28, respectively). Lean sedentary participants are also very likely to have endothelial dysfunction (OR- = 1.59) and arterial stiffness (OR = 2.15). Receiver-operating characteristic curve analysis demonstrated that body mass index (BMI) and arm circumderence (AC) are better predictors of increased PWV in sedentary than physically active study participants (AUC was 0.96, 0.95, 0.50 and 0.56, respectively). Blood pressure variables were stronger predictors than BMI and AC for increased PWV and EAA in physically active participants and better predictors of increased AixBrach in the sedentary group.

Conclusions:

Physical activity improves arterial stiffness, endothelial dysfunction and arterial age even in obese and overweight subjects. BMI and AC are better predictors of arterial stiffness in sedentary than in physically active subjects. Blood pressure variables are better predictors of arterial stiffness and EAA than BMI and AC in physically active participants and of endothelial dysfunction in sedentary individuals.

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