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Sex differences in antihypertensive treatment have often been highlighted, but whether there is truly a difference or whether this difference is mediated by confounding factors has yet to be deciphered.We performed a cross-sectional study on the first consultation in the Georges Pompidou Hospital Tertiary Hypertension Unit between July 2000 and June 2015 to explore sex differences in both patient and treatment characteristics over this period.A total of 17 856 patients were included. We observed in both women and men an increase in blood pressure control over time despite having more comorbidities. In conjunction, there was an increasing number of treated patients and treatments per patient. The treatments previously selected by the referring physicians strongly differed by sex: women were more frequently treated with loop diuretics [odds ratio (OR) = 1.2 (95% confidence interval (CI): 1.05–1.37)], thiazide diuretics [OR = 1.13 (95% CI: 1.03–1.23)], aldosterone-receptor blockers [OR = 1.41 (95% CI: 1.24–1.61)], and beta blockers [OR = 1.53 (95% CI: 1.41–1.66)] but less frequently with angiotensin-converting enzyme inhibitors [OR = 0.77 (95% CI: 0.70–0.84)], angiotensin II-receptor blockers [OR = 0.93 (95% CI: 0.86–1.0)], and calcium channel blockers [OR = 0.72 (95% CI: 0.67–0.78)] than men after adjusting for various patient-related confounding factors.Blood pressure control has greatly improved over the last 15 years in both men and women. Although the treatment choice remained strongly dependent on sex, this is not justified by a sex-related difference in cardiovascular benefit from antihypertensive treatment.