5 ORTHOSTATIC HYPERTENSION IN NORMOTENSIVE YOUNG ADULTS WITH FAMILY HISTORY OF HYPERTENSION

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Abstract

Background:

Normotensive young adults with family history of hypertension are human model of pre hypertension, as they have structural and functional changes in the cardiovascular system. Cardiovascular reactivity is the response of the cardiovascular system to the laboratory or natural stimuli, including to postural changes. The exaggerated cardiovascular reactivity is related to structural and functional changes in the cardiovascular system.

Objective:

To observe whether normotensive young adults with family history of hypertension have exaggerated cardiovascular response to postural changes.

Methods:

Male and female undergraduate normotensive young adults with (n = 16) and without (n = 14) hypertensive parents did postural changes from supine to standing. The median value of the delta systolic blood pressure, diastolic blood pressure and pulse rate from all samples were used to classified exaggerated cardiovascular responses. Data were analyzed with Chi square. P value <0.05 was considered significant.

Results:

Proportion of normotensive young adults who had exaggerated systolic (>3.5 mmHg) or diastolic (>2 mmHg) blood pressure responses to postural changes were significantly higher in those with parental history of hypertension as compared to those without parental history of hypertension. Proportion of normotensive young adults who had exaggerated pulse rate (>12 bpm) response to postural changes was not significantly different between the two groups.

Conclusion:

Normotensive young adults with family history of hypertension may have orthostatic hypertension.

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