16 THE IMPACT OF STATIN FOR PRIMARY PREVENTION ON BLOOD PRESSURE, ARRHYTHMIA EVENTS AND MORTALITY AMONG ACUTE CORONARY SYNDROME PATIENTS

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Abstract

Background:

Acute coronary syndrome (ACS) is the greatest single cause of mortality and loss of disability-adjusted-life-years(DALYs) worldwide. Thus, optimal primary prevention is needed to reduce the mortality of ACS. One of the modalities used for prevention is statin due to its various pleiotropic effects. This study therefore aims to evaluate the impact of statin use prior to the onset of ACS and its effects on blood pressure, arrhythmia events and mortality after ACS onset in samples from Indonesia.

Method:

Medical records of ACS patients are obtained from Cengkareng General Hospital during the period January-December 2016. Diagnosis of ACS was determined based on clinical and laboratory findings obtained from the medical records.

Result:

One-hundred-and-twenty-patients were found with ACS with a mean age of 56 years old. 73.3% suffered from STEMI while 26.7% suffered from NSTEMI. Only 15 patients were found to use statin before the onset of ACS. All ACS patients have markedly higher cardiac marker levels. Eleven-mortalities (9.2%) were found. Both mean systolic and diastolic blood-pressure was found to be higher in the non-statin group although they were not statistically-significant. Equal number of arrhythmia event was found in both groups. Statin use was associated with lower risk of mortality(OR: 0.679, CI: 0.081-5.72) although it was statistically non-significant.

Conclusion:

The above results showed that there is no significant statistical differences in blood pressure and arrhythmia events between patients using statin prior to ACS onset and those who do not. However, statin use was clinically associated with lower risk of mortality.

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