To assess the associations of resting heart rate (RHR) with all-cause, cardiovascular and non-cardiovascular mortality in Chinese population suffering from hypertension using a prospective urban and rural epidemiology study in China (PURE-China).Methods:
A total of 46,285 participants aged 35–70 years were recruited and 14,263 participants suffering from hypertension were included in this analysis. Resting heart rate was measured in baseline survey by trained health workers. The main clinical outcomes were cardiovascular mortality, non-cardiovascular mortality, and total mortality. Kaplan-Meier curves and Cox frailty models with center as random effect were used to assess above-mentioned associationsResults:
The median RHR was 74.5 beats per minute (bpm) with interquartile range of 67.5–82.0 among hypertension patients at baseline. During total observational time of 136,259 person-years with a median of 9.6 years, 426 cardiovascular death events, 434 non-cardiovascular death events were documented. In adjusted analysis, participants with RHR > 70.0 were more likely to die (hazard ratio [HR] per 10 bpm, 1.14; 95% confidence interval [CI], 1.09–1.20; P < 0.001); similarly, higher resting heart rate was associated with a higher risk of cardiovascular mortality (HR, 1.16; 95% CI, 1.08–1.25; P < 0.001) and non-cardiovascular mortality (HR, 1.11; 95% CI, 1.03–1.19; P = 0.009) (Figure 1).Conclusion:
Monitoring of RHR may play an important role on reducing mortality risk among hypertension patients.