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The aim of this study was to analyze the effect of lifestyle intervention on blood pressure and cognitive function in occupational population with hypertension in China.Cluster sampling was conducted in September, 2013, in Shaanxi Jinduicheng (intervention group) and Shaanxi Hancheng (control group). The intervention group received regular lifestyle intervention for 2 years, which included diet, smoke, drink and exercise intervention. Mild cognitive impairment (MCI)was measured by the Montreal Cognitive Assessment (MoCA).We conducted BP measurement and MoCA questionnaire at baseline,6,12 and 24 months.We analyzed a total of 510 subjects, whose average age was 45.6 ± 13.4 years old.With the increase of BP level, the MoCA scores decreased significantly both in control and lifestyle intervention groups (P < 0.05).There was no obvious differences between the hypertensive patients whose age was between 45 and 59 to those under 45 (P > 0.05).After 2 years, the BP,TC and glucose of the lifestyle intervention subgroup and lifestyle intervention plus medication subgroup decreased (P < 0.05), and the MoCA scores increased (P < 0.05). Compared with the control group, the BP and MoCA scores had no obvious changes at 6 months (P > 0.05), but the BP decreased and the MoCA scores increased significantly in the intervention group after 1 year and 2 years of lifestyle intervention (P < 0.05).Long-term lifestyle intervention can be used as adjunctive therapy to improve the blood pressure and cognitive function of hypertensive occupational population in China.