A9796 Effect of Long-term Lifestyle Intervention on Mild Cognitive Impairment in Hypertensive Occupational Population in China

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Objectives:The aim of this study was to analyze the effect of lifestyle intervention on blood pressure and cognitive function in occupational population with hypertension in China.Methods:Cluster sampling was conducted in September, 2013, in Shaanxi Jinduicheng (intervention group) and Shaanxi Hancheng (control group). The intervention group received regular lifestyle intervention for 2 years, which included diet, smoke, drink and exercise intervention. Mild cognitive impairment (MCI)was measured by the Montreal Cognitive Assessment (MoCA).We conducted BP measurement and MoCA questionnaire at baseline,6,12 and 24 months.Results:We analyzed a total of 510 subjects, whose average age was 45.6 ± 13.4 years old.With the increase of BP level, the MoCA scores decreased significantly both in control and lifestyle intervention groups (P < 0.05).There was no obvious differences between the hypertensive patients whose age was between 45 and 59 to those under 45 (P > 0.05).After 2 years, the BP,TC and glucose of the lifestyle intervention subgroup and lifestyle intervention plus medication subgroup decreased (P < 0.05), and the MoCA scores increased (P < 0.05). Compared with the control group, the BP and MoCA scores had no obvious changes at 6 months (P > 0.05), but the BP decreased and the MoCA scores increased significantly in the intervention group after 1 year and 2 years of lifestyle intervention (P < 0.05).Conclusion:Long-term lifestyle intervention can be used as adjunctive therapy to improve the blood pressure and cognitive function of hypertensive occupational population in China.

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