A10781 Prognostic value of cardiovascular risk factors in hypertensive versus non-hypertensive middle-aged and elderly subjects

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Abstract

Objectives:

to evaluate the 14-year prognostic impact of conventional cardiovascular (CV) risk factors and biomarkers in subjects with- versus without hypertension.

Methods:

678 middle aged and elderly subjects with no previous or known CV disease from Copenhagen Holter Study (CHS) were included. All were studied by interview, clinical examination, 48 hour Holter recording and laboratory testing. Fourteen years rate of CV endpoints (CV death, stroke, or acute myocardial infarction) were evaluated by meticulous evaluation of patient files and registry search. Hypertension was defined as BP > 14/90 or use of antihypertensive medications. Cox proportional models were used to evaluate the impact of risk factors in each group.

Results:

There were 491 hypertensive and 187 normotensive, with 111 (22.5%) and 28 (15%) CV-endpoints, respectively (p = 0.02). Table 1 and 2 show the prognostic value of CV risk factors in Hypertensives and normotensives. Parameter P-value Hazard Ratio 95% Confidence Intervals Label sex < .0001 2.773 1.788 4.300 male Age < .0001 1.100 1.063 1.139 5-year increment Diabetes 0.0005 2.562 1.514 4.338 Smoking 0.0018 1.961 1.284 2.995 current smoker Night SDNN 0.0053 0.986 0.977 0.996 Night heart rate variability ESVEA 0.0208 1.762 1.090 2.848 Excessive supraventricular activity Log-BNP 0.0088 1.285 1.065 1.550 NT-proBNP Table1-Hypertensives Parameter DF Pr > ChiSq Hazard Ratio 95% Confidence Limits Label Systolic BP 1 0.0256 1.068 1.008 1.131 Systolic blood pressure Hs CRP 1 0.0221 2.544 1.143 5.658 HS CRP > 3 μg/l Table 2_ Normotensives

Conclusion:

Conclusions: While most CV risk factors have an impact in hypertensives, only inflammation and BP do have a prognostic impact in normotensives.

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