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Excess dietary salt is strongly correlated with cardiovascular disease, morbidity, and mortality. In epidemiological studies, increased plasma osteoprotegerin (OPG) concentrations are associated with atherosclerosis, stroke, diabetes mellitus, and vascular mortality. Our study was designed to examine the effects of salt intake and potassium supplementation on plasma OPG levels in normotensive subjects.Eighteen normotensive subjects (aged 25 to 50 years) were selected from a rural community in northern China. They were sequentially maintained on a normal diet for 3 days at baseline, low-salt diet for 7 days (3 g/day, NaCl), high-salt diet for 7 days (18 g/day). OPG concentration was measured through ELISA.High-salt intake enhanced plasma OPG levels (252.7 ± 13.9 pg/ml vs. 293.4 ± 16.1 pg/ml). Further analyses revealed that the OPG concentration was positively correlated with 24 h urinary sodium excretion (r = 0.497, P < 0.01).Salt loading can enhance the production of circulating OPG. Our study may improve our understanding of the roles of salt in the risk of cardiovascular disorders.