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The study was aimed at assessing the knowledge, attitudes and practices regarding tobacco consumption.This was a cross-sectional study where 1140 adults between 15 to 65 years were selected from the outpatient departments of government hospitals purposively chosen from seven divisions of Bangladesh in 2015. Data were collected through face-to-face interview using a semi-structured pretested questionnaire.The prevalence of tobacco use among the respondents was 35.1%; among them almost half (47.5%) of the respondents used smoking tobacco, 43.0% used smokeless tobacco and 9.5% used both form of tobacco, smoke and smokeless. Most of the smokers (92.9%) smoked cigarettes whereas 67.8% smokeless tobacco users used jarda. The mean age of initiation of smoking and smokeless tobacco was 19.5 ( ± 4.5) and 26.03 ( ± 9.7) years respectively. Significant differences (p < 0.05) in tobacco consumption were found for sex, age group, educational level and occupational status. Almost all respondents had knowledge of health hazards due to tobacco consumption, which they learned from the mass media. Significant differences (p < 0.05) were found for knowledge regarding health hazards of tobacco use by age group, educational level, occupational status, monthly income and expenditure. Influencing factors for smoking were family, friends, community and media. Female gender, productive age group 25–64 years, and monthly family income were associated (p < 0.05) with tobacco consumption.Almost all the respondents had very good knowledge on health hazards related to tobacco consumption irrespective of gender but they were not that much motivated which is reflected in their practices.