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The prognostic impact of each of the CV risk factors is normally modified and defined by the background risk burden. Hypertension is the most significant and frequent risk factor in the population. Thus, the burden of other risk factors may be different in subjects with versus without hypertension. The objectives were to evaluate the 14-year prognostic impact of conventional cardiovascular (CV) risk factors and biomarkers in subjects with versus without hypertension.678 middle aged and elderly subjects with no previous or known CV disease from Copenhagen Holter Study were included. All were studied by interview, clinical examination, 48 hour Holter recording and laboratory testing. Fourteen years rate of CV endpoints (CV death, stroke, or acute myocardial infarction) were evaluated by meticulous evaluation of patient files and registry search. Hypertension was defined as blood pressure > 140/90 or the use of antihypertensive medication. Cox proportional models were used to evaluate the impact of risk factors in each group.There were 491 hypertensive and 187 normotensive subjects, with 111 (22.5%) and 28 (15%) CV-endpoints respectively (p = 0.02). Table 1a and 1b shows the prognostic value of CV risk factors in hypertensives and normotensives.While most CV risk factors have an impact in hypertensives, only inflammation and BP do have a prognostic impact in normotensives.