A17446 IMPACT OF THE HYPERTENSION AND CAROTID INTIMA-MEDIA THICKNESS TO THE INFARCTS VOLUME IN THE STROKE PATIENTS

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Abstract

Objectives:

Cognitive deficit among hypertensive elderly patients with brain infarcts was established during last years, represents the basis of vascular dementia in late life still, but their link with intima media thickness (IMT) remains controversially as well as the stroke volume The aim of this study was assesment of IMT among hypertensive poststroke patients (PSL) with lacunar lesions (MSL)

Methods:

Prospective study of 147 (mean age 71,4) patients was carried out. The patients were divided in two groups: I group (85)-moderate stroke patients without hypertension. Type, side and site of stroke was assesed by conventional MRI. II group (62)-moderate/severe hypertensive stroke patients,who had multiple lacunar lesions in MRI. Cognitive function was investigated in both groups by neuropsychological battey (letter fluency, Stroop test,Wisconsin Card Sorting Test, digit span, letter number sequensing), MMSE.. Ultrasonographically assessed carotid artery IMT. They were compaired due to vascular risk factors, clinical, demographic and radiological variables. Statistical evaluation was perform by SPSS

Results:

From 85 PSL patients dementia was diagnosed in13 (15,2%). cases,depression in 24 (28,2%). This group often had damage of the left hemisphere, prevalence of ischemic with basal ganglia lesions. No one from the 65 MSL patients had dementia, but 29 (44,6%) had mild cognitive impairment and 36 (55.3%) had depression. Atherogenic index and Crotid Intima-Media Sickness was significantly higher in patients with multiple lacunar infarction lesion and associated with hypertension, age and female gender

Conclusion:

Carotid IMT predicts an increased risk for cognitive impairment, particularly poor memory and cognitive speed, in elderly women, and leads to multiple lacunar silent infarct lesions

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