A12048 The effects of nitrendipine/atenolol combination tablets on the blood lipid level in the patients with mild-to-moderate essential hypertension---A prospective study of single treatment group

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Abstract

Objectives:

To observe the effects of nitrendipine/atenolol combination tablets (abbreviation as Nile) on the blood lipid level, when use it to treat hypertension in the patients with mild-to-moderate essential hypertension

Methods:

We selected 2 villages from Donghai and Haian county. The residents aged from 18–70 years old were cluster sampled for hypertension screening. 341 patients with mild-to-moderate essential hypertension were recruited according the inclusion criteria. The patients were treated with Nile for 6 months according to the treatment proposal; and the blood pressure, adverse effects, severity events and so on were monitored regularity. The correlated biochemical indicator (including blood lipid) were detected after recruited and at the end of 6 month treatment

Results:

The control rate of blood pressure in the patients was 90.91%. The levels of TG and HDL-C were significant increased after the 6 month treatment, however, the level of TC had not difference. In male patients, the level of HDL-C was increased from 1.02 ± 0.43 to 1.27 ± 0.44mmol/L, and the level of triglyceride increased from 1.46 ± 1.12 to 2.24 ± 2.07mmol/L. In female patients, the level of HDL-C increased from 1.01 ± 0.40 to 1.22 ± 0.29 mmol/L. The abnormal rate of HDL-C in female patients decreased from 63.43% to 30.29% before and after the treatment, the abnormal rates of triglyceride and total cholesterol had not significant change. In male patients, the abnormal rate of HDL-C decreased from 57.83% to 25.90%, the abnormal rate of triglyceride increased from 14.46% to 33.13%

Conclusion:

The treatment of Nile has a significant effect on the blood lipid level in hypertension patients, especially to increase the HDL-C level; it has also effect on the triglyceride level in the male hypertension patients

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