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Cystatin c (Cys c) is a good indicator in early renal dysfunction. Blood pressure variability (BPV) is closely related to target organ damage, especially the kidney. We aimed to explore Cys c level and the relationship with BPV in hemorrhage strokes.A total of 141 first-ever hemorrhage stroke cases were recruited in our study. Cys c, blood uric acid, blood creatinine were determinate and 24-hours ambulatory blood pressure for the first 7 consecutive days (7-day/24-hours) were monitored. Standard deviation was used to describe the BPV. Patients were divided into low BPV group (L-BPV) and high BPV group (H-BPV) according to the median of the 7-day/24-hours BPV. Described methods, univariateanalysis and multiple linear regressions were used for analysis.The concentration of Cys c in H-BPV group (1.01 ± 0.38 mg/L) was higher than that in L-BPV group (0.85 ± 0.41 mg/L), (t = 2.35, P = 0.02). The 7-day/24-hours BPV of systolic blood pressure (SBP) in H-BPV group (17.21 ± 2.76)was higher than that of L-BPV group (11.14 ± 1.78), (t = 15.47, P = 0.001). The 7-days SBP BPV was positively correlated with Cys c level (r = 0.34, P = 0.001). Multiple linear regression analysis showed that 7-days/24-hours SBP BPV, serum creatinine, blood uric acid, gender and age were the main influencing factors of cys c level (all P < 0.05).BPV was the important influencing factors for Cystatin c level and may be an useful indicator for early renal dysfunction in acute hemorrhage stroke.