A16349 Urine sodium, urine potassium, urine sodium to potassium ratio and Ambulatory blood pressure monitoring (ABPM) in Chinese population


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Abstract

Objectives:It remains controversial about whether there exists a J-shaped association between urine sodium (UNa), urine potassium(UK), urine sodium to potassium ratio(NaK) and blood pressure.Limited study evaluated this association with ambulatory blood pressure monitoring (ABPM).The purpose of study was to assess the relationship between urine electrocytes and ABPM measuresMethods:We conducted across-sectional analysis in2271 people (47.12% female) at a mean age of 56.26.39 ± 19.42with an average clinic BP 148.04 ± 20.45/ 89.15 ± 15.15 mmHg from south to north across 15 cities China. We treated UNa, UK, NaK as both continuous and categorical variables to analyze their association with blood pressure. We also performed stratified analysis according to Una and NaK quartilesResults:The average of Una, UKand ABPM BP were 147.44 ± 79.26, 39.38 ± 19.23mmol/d, 24 h: 131.99 ± 17.79/ 80.33 ± 13.46 mmHg, day: 135.03 ± 26.94/ 82.19 ± 13.55 mmHg, night: 125.89 ± 18.77/ 75.48 ± 13.10 mmHg. The median of NaK was 3.76. UNa and NaK were significantly positively associated with all BP (UNa: β ranged from 0.64 – 0.80 for SBP, 0.46 – 0.51 for 24 h, DBP; NaK: β ranged from 0.02 – 0.03 SBP, 0.01 – 0.02 for DBP. See table) in full adjusted model. When treated as quartiles, theygenerally showed a monotonically increasing pattern. In stratified analysis, the sign of coefficient for different strata did not indicate a J-shape associationConclusion:UNa and NaKhave a positive association with ABPMBPin Chinese people.In our study, there was no sufficient evidence that supported the existence of a J-shape relationship

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