A18142 Regular endurance exercise decreases blood pressure via enhancement of angiogenesis and VEGF expression in spontaneously Hypertensive Rats

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Abstract

Objectives:

This study investigated the effect of endurance exercise on blood pressure, angiogenesis and vascular endothelial growth factor (VEGF) expression in skeletal muscle of spontaneously hypertensive rats (SHR).

Methods:

SHR and WKY of 5 weeks ages were randomly divided into 3 groups; Wistar-Kyoto rat (WKY, n = 9), SHR control (SHR-C, n = 9), and SHR endurance exercise training (SHR-E, n = 9). Endurance exercise training was performed on treadmill (12–20 m/min, 0% grade, 60 min/day, 5 days/week, 16 weeks). Systolic blood pressure was monitored with tail-cuff method, expression of VEGF protein and capillary density were used with western blotting and H&E staining in the soleus muscle, respectively.

Results:

Systolic blood pressure was reduced by endurance exercise in SHR (p < .05). Capillary density of skeletal muscle in SHR-C was lower than WKY (p < .05), but it was recovered by endurance exercise training (SHR-E) compare to SHR-C (p < .05) and VEGF protein also was increased by endurance exercise training compare to SHR-C (p < .05).

Conclusion:

These data suggest that enhancement of capillary density via increase of VEGF expression in skeletal muscle by endurance exercise training could be important factor to inhibit elevation of blood pressure of SHR.

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