01 Adsorption and wetting of protein affected by bionic surface texture desig nfor artificial organs application


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Abstract

BackgroundSurface texture has been widely used in functional surface design. Protein adsorption on the surface plays an impmtant role in improving biocompatibility of materials for aitificial organs development.MethodsAnay of bionic surface texture was fabricated on the surface of titanium alloy to imitate the surface of artificial organs. Experiments of BSA protein adso rption were perfonned on the different surface textures under stead body temperature of 38 degree centigrade for 4 hours. Property of absorption and wetting were characterized by polarizing microscope, scanning electron microscope and contact angle meter.ResultsResults showed that BSA adsorption decreased with the increasing of surface texture depths and ratios, and tended to be stable finally. The wetting property became poorer as the surface texture depths and ratios increased. There was a remarkab le conelation between them. However, High levels of texture depths and density may lead to the negative influence on the tribo logical property of the surface.ConclusionBionic surface texture has obvious influence on the adsorption and wetting of protein. Proper parameters of bionic surface texture may be of importance for the surface design in the real specific application.AcknowledgmentSupported by a project grant from the Science and Technology Innovation Fund (Grand No. 2014kct-03).

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