06 Hemicellulose-based magnetic hydrogel for enzyme drug immobilisation

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Abstract

Background

In recent years, magnetic hydrogels have attracted much attention and have been used in remote controlled drug release and cancer treatment.

Methods

Hemicellulose/PAAc semi-IPN magnetic hydrogel was synthesised from wheat straw hemicellulose and Fe3O4 nanoparticles using H2O2-Vc as redox initiator system. The Fe3O4 nanoparticles were prepared via the solvothermal method and modified with triethoxyvinylsilane. The magnetic hydrogels were characterised by FT-IR, SEM and VSM, and the swelling property and enzyme immobilisation of the hydrogels were also studied.

Results

The result demonstrated that the magnetic hydrogels had excellent pH sensitivity and magnetic properties, and the M-H hysteresis curve showed the superparamagnetic property of the magnetic hydrogels. The adsorption isotherm study of lysozyme demonstrated that both the Freundlich and Temkin isotherm models are suitable for describing the adsorption of lysozyme on HC/PAAc semi-IPN magnetic hydrogels.

Conclusion

The swelling property and high immobilisation capacity of HC/PAAc semi-IPN magnetic hydrogel could expand its applications in drug delivery.

Acknowledgements

Supported by Natural Science Basic Research Plan in Shaanxi Province of China (No. 2017JM2003), and the Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University (No. Z2017204).

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