17 Effect of salvia miltiorrhiza on tmmrna expression in coronary artery tissue of rats with high salt induced blood stasis

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Abstract

Objective

To understand the effect of Salvia miltiorrhiza on the cardiovascular system by the expression of tissue TMmRNA, and to provide the scientific basis for the use of Salvia miltiorrhiza and a low salt diet for the prevention and treatment of cardiovascular and cerebrovascular diseases caused by high salt intake.

Methods

Thirty SD rats were randomly divided into a blank group, high salt group and Salvia miltiorrhiza group. The blank group was given intragastric distilled water and the high salt and the Salvia miltiorrhiza groups were treated with intragastric administration of 12% NaCl, for 30 consecutive days. Seven days before finishing this model, sterile water was injected intraperitoneally every afternoon in the blank group and the high salt group while, in the Salvia miltiorrhiza group, an injection of Salvia miltiorrhiza was given every afternoon. Then the animals were killed and the coronary arteries were removed. The expression of thrombomodulin mRNA (TMmRNA) in the coronary arteries of the rats in each experimental group was detected by the RT-PCR technique.

Result

Compared with the blank group, the expression of TMmRNA in the coronary tissue of the high salt group was obvious (p<0.01). There was no significant difference between the Salvia miltiorrhiza group and the blank group (p>0.05). Compared with the high salt group, the expression of TMmRNA in the coronary tissue of the Salvia miltiorrhiza was significantly different (p<0.01). It was suggested that the expression of TMmRNA in coronary artery tissue was related to the high salt diet. The expression of TMmRNA in coronary artery tissue was down-regulated by Salvia miltiorrhiza.

Conclusion

Salvia miltiorrhiza can reduce the expression of TMmRNA in the tissue of blood stasis caused by high salt, promote the repair of blood vessel endothelium and blood movement, and can effectively improve the damaged coronary artery.

Acknowledgements

Supported by a project grant from Natural Science Foundation of China (Grant No. 81503476).

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