This article provides an overview of the issues that affect the use and proliferation of safety infusion products. In particular, the associated risks and benefits of needleless infusion systems are discussed. Recent legislation and regulations address healthcare worker exposure to bloodborne pathogens and mandate the use of these devices to mitigate the risk of healthcare worker exposure to bloodborne pathogens. This article examines whether safety devices increase the risk for catheter-related infections among patients, and evaluates the implications for clinical practice and compliance. Clinician education and standards of care also are discussed as methods to ensure the optimal safety of both healthcare workers and the patients for whom they are responsible.