Biotinylation of aminopyridine-based macrocycles and metallomacrocycles and inclusion of biotinylated iron(II) complex in avidin

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A simple methodology for single-site conjugation of macrocycles and metallomacrocycles with biotin is presented. This method has been used to conjugate a redox-active macrocyclic complex and embed it into avidin. The resulting biotin-metal complex-avidin adduct exhibits peroxidase activity as shown by the oxidation of ABTS and pyrogallol with H2O2.

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