Characterization of second coordination shell ionophore–siderophore host–guest assemblies and binding selectivities in binary and complex mixtures by electrospray ionization mass spectrometry

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An ESI-MS method for the determination of host–guest association constants and binding selectivities for systems of binary and complex mixtures, respectively, is presented in an effort to quantitatively study the strength of host–guest interactions, while accounting for the different ESI-MS spray efficiencies of each component. Association constants were obtained for host–guest complexes formed between a series of crown ether and linear ionophore hosts and various guests, including protonated amines, and an apo- and ferri-siderophore, ferrioxamine B.

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