The Effects of Stimulation Parameters on Clinical Outcomes in Patients With Vagus Nerve Stimulation Implants With Major Depression

    loading  Checking for direct PDF access through Ovid


Stimulation techniques, such as vagus nerve stimulation, are a promising new approach for treatment-resistant depression. Most international studies have used fixed stimulation parameters or have varied the stimulation frequencies. Our retrospective examination of 2 parallel groups of 10 patients each compared low-strength/high-frequency vagus nerve stimulation parameters (≤1.5 mA, 20 Hz) with high-strength/low-frequency ( >1.5 mA, 15 Hz) parameters. We found a significant decrease in the Hamilton Rating Scale for Depression scores in patients who were treated using the low-strength/high-frequency stimulation parameters. In contrast, the scores of the patients treated with high-strength/low-frequency stimulation did not change.

Related Topics

    loading  Loading Related Articles