Disseminated tuberculosis involving the uterine cervix and central nervous system is described in a 26-year-old Native American female with new-onset seizures. Her presenting complaint was generalized seizures with associated weight loss, chronic cough, global headache, and malaise. Pelvic examination revealed an exophytic cervical mass consistent with carcinoma. Laboratory results showed anemia, hypoalbuminemia, and radiodensities on chest radiography. Cultures of sputum and cervix were positive for Mycobacterium tuberculosis. Cervical biopsies revealed multiple acid-fast bacilli. Computed tomography of the head showed multiple tuberculomas. The patient was treated with multidrug antituberculous therapy for 6 months, with resolution of seizures and improvement in computed tomographic findings.