The baboon model (: maternal weight, age, reproductive history and pregnancy outcomePapio hamadryas: maternal weight, age, reproductive history and pregnancy outcome) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome

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Abstract

Background

Several risk factors are associated with the incidence of human stillbirths. The prevention of stillbirths in women is a pressing clinical problem.

Methods

We reviewed 402 pathology records of fetal loss occurring in a large baboon (Papio spp.) colony during a 15-year period. Clinical histories of 565 female baboons with one or more fetal losses during a 20-year period were analyzed for weight, age, and reproductive history.

Results

Fetal loss was most common at term (35.57%) and preterm (28.61%) and less common in the first half of gestation (11.20%) and post-term (5.22%). Greater maternal weight, older age, history of stillbirth and higher parity were independent predictors for stillbirth. An exponential increase in the incidence of fetal loss was observed beginning at age 14 years in baboons.

Conclusions

Fetal loss and maternal risk factors associated with stillbirths in baboons were similar to those documented in women.

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