Free-breathing high-spatial-resolution delayed contrast-enhanced three-dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

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Abstract

Purpose:

To assess the feasibility of free-breathing high-spatial-resolution delayed contrast-enhanced three-dimensional (3D) viability magnetic resonance imaging (MRI) at 3.0T for the detection of myocardial damages.

Materials and Methods:

Twenty-five patients with myocardial diseases, including myocardial infarction and cardiomyopathies, were enrolled after informed consent was given. Free-breathing 3D viability MRI with high spatial resolution (1.5 × 1.25 × 2.5 mm) at 3.0T, for which cardiac and navigator gating techniques were employed, was compared with breath-hold two-dimensional (2D) viability imaging (1.77 × 1.18 × 10 mm) for assessment of contrast-to-noise ratio (CNR) and myocardial damage.

Results:

Free-breathing 3D viability imaging was achieved successfully in 21 of the 25 patients. This imaging technique depicted 84.6% of hyperenhancing myocardium with a higher CNR between hyperenhancing myocardium and blood and with excellent agreement for the transmural extension of myocardial damage (k = 0.91). In particular, the 3D viability images delineated the myocardial infarction and linear hyperenhancing myocardium, comparable to the 2D viability images.

Conclusion:

Free-breathing high-spatial-resolution delayed contrast-enhanced 3D viability MRI using 3.0T was feasible for the evaluation of hyperenhancing myocardium, as seen with myocardial infarction and cardiomyopathies. J. Magn. Reson. Imaging 2008;28:1361–1367. © 2008 Wiley-Liss, Inc.

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