Optimizing MRI scan time in the computation of pharmacokinetic parameters (Ktrans) in breast cancer diagnosis

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Abstract

Purpose:

To assess the effects of reduced scan time in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast for the evaluation of pharmacokinetic parameters (Ktrans, ve, and kep).

Materials and Methods:

High temporal resolution DCE-MRI was performed for calculation of pharmacokinetic parameters (Ktrans, ve, and kep) at different timepoints using an in-house developed computation scheme adopting the standard model (SM).

Results:

The receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) of 0.994 for Ktrans at 90 seconds and 0.987 for Ktrans at 60 seconds with a significant decrease in the AUC for Ktrans at 30 seconds (0.669). While ve showed a consistently higher AUC (>0.9) at timepoints ≥40 seconds, the AUC for kep showed a consistent decline with reduced acquisition times.

Conclusion:

Reducing the acquisition time for the Ktrans and ve measurement up to 60 seconds yields reasonable accuracy for both and can be incorporated in the routine DCE-MRI protocol for evaluation of enhancing breast lesions. J. Magn. Reson. Imaging 2013;38:573–579. © 2013 Wiley Periodicals, Inc.

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