Optimizing MRI scan time in the computation of pharmacokinetic parameters (Ktrans) in breast cancer diagnosis

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To assess the effects of reduced scan time in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast for the evaluation of pharmacokinetic parameters (Ktrans, ve, and kep).

Materials and Methods:

High temporal resolution DCE-MRI was performed for calculation of pharmacokinetic parameters (Ktrans, ve, and kep) at different timepoints using an in-house developed computation scheme adopting the standard model (SM).


The receiver operating characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) of 0.994 for Ktrans at 90 seconds and 0.987 for Ktrans at 60 seconds with a significant decrease in the AUC for Ktrans at 30 seconds (0.669). While ve showed a consistently higher AUC (>0.9) at timepoints ≥40 seconds, the AUC for kep showed a consistent decline with reduced acquisition times.


Reducing the acquisition time for the Ktrans and ve measurement up to 60 seconds yields reasonable accuracy for both and can be incorporated in the routine DCE-MRI protocol for evaluation of enhancing breast lesions. J. Magn. Reson. Imaging 2013;38:573–579. © 2013 Wiley Periodicals, Inc.

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