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To examine the role of socioeconomic variables on middle-aged adult men's knowledge and health beliefs about osteoporosis.An anonymous survey used validated scales to assess osteoporosis knowledge and health beliefs in a sample of 262 men aged 36–55 years. Descriptive and group-differences statistics (MANOVA and ANOVA) were used.Total osteoporosis knowledge was low (mean, 11.1 of 22) and mean scores on perceived susceptibility and seriousness health belief domains were also low: 13.2 and 17.2, respectively out of 30. Multivariate ANOVA revealed that perceived seriousness, barriers to calcium intake, and health motivation varied significantly with level of formal education attained (P < .05). There was no significant difference with income.Results of this convenience sample of predominantly white men found that level of osteoporosis knowledge and perceived susceptibility were low. Given the increased prevalence of osteoporosis-related fracture in men, methods to increase knowledge and awareness are needed.